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Starting building block: Ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate CAS 256504-39-9 Core advanced scaffold intermediate: Ethyl 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylate CAS 1361232-72-5 As a first-in-class sGC stimulator, vericiguat significantly cuts cardiovascular mortality & HF readmission risks for chronic HFrEF patients, with rapidly expanding global formulation capacity
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Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster
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